WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:p53 signaling pathway       ID:04115
C=68; O=3; E=0.16; R=18.29; rawP=0.0006; adjP=0.0105
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000106366 NA SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 5054 ENSG00000106366
2  ENSG00000124762 NA CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1026 ENSG00000124762
3  ENSG00000099860 NA GADD45B growth arrest and DNA-damage-inducible, beta 4616 ENSG00000099860


Database:KEGG pathway       Name:Cell cycle       ID:04110
C=124; O=3; E=0.30; R=10.03; rawP=0.0034; adjP=0.0105
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000124762 NA CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1026 ENSG00000124762
2  ENSG00000136997 NA MYC v-myc myelocytomatosis viral oncogene homolog (avian) 4609 ENSG00000136997
3  ENSG00000099860 NA GADD45B growth arrest and DNA-damage-inducible, beta 4616 ENSG00000099860


Database:KEGG pathway       Name:ErbB signaling pathway       ID:04012
C=87; O=3; E=0.21; R=14.30; rawP=0.0012; adjP=0.0105
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000124762 NA CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1026 ENSG00000124762
2  ENSG00000109321 NA AREG amphiregulin 374 ENSG00000109321
3  ENSG00000136997 NA MYC v-myc myelocytomatosis viral oncogene homolog (avian) 4609 ENSG00000136997


Database:KEGG pathway       Name:MAPK signaling pathway       ID:04010
C=268; O=4; E=0.65; R=6.19; rawP=0.0041; adjP=0.0105
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000136997 NA MYC v-myc myelocytomatosis viral oncogene homolog (avian) 4609 ENSG00000136997
2  ENSG00000099860 NA GADD45B growth arrest and DNA-damage-inducible, beta 4616 ENSG00000099860
3  ENSG00000115590 NA IL1R2 interleukin 1 receptor, type II 7850 ENSG00000115590
4  ENSG00000130522 NA JUND jun D proto-oncogene 3727 ENSG00000130522


Database:KEGG pathway       Name:Alanine, aspartate and glutamate metabolism       ID:00250
C=32; O=2; E=0.08; R=25.92; rawP=0.0027; adjP=0.0105
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000131459 NA GFPT2 glutamine-fructose-6-phosphate transaminase 2 9945 ENSG00000131459
2  ENSG00000135821 NA GLUL glutamate-ammonia ligase 2752 ENSG00000135821


Database:KEGG pathway       Name:Cytokine-cytokine receptor interaction       ID:04060
C=265; O=4; E=0.64; R=6.26; rawP=0.0040; adjP=0.0105
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000027697 NA IFNGR1 interferon gamma receptor 1 3459 ENSG00000027697
2  ENSG00000115604 NA IL18R1 interleukin 18 receptor 1 8809 ENSG00000115604
3  ENSG00000135503 NA ACVR1B activin A receptor, type IB 91 ENSG00000135503
4  ENSG00000115590 NA IL1R2 interleukin 1 receptor, type II 7850 ENSG00000115590


Database:KEGG pathway       Name:Osteoclast differentiation       ID:04380
C=128; O=3; E=0.31; R=9.72; rawP=0.0037; adjP=0.0105
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000027697 NA IFNGR1 interferon gamma receptor 1 3459 ENSG00000027697
2  ENSG00000075426 NA FOSL2 FOS-like antigen 2 2355 ENSG00000075426
3  ENSG00000130522 NA JUND jun D proto-oncogene 3727 ENSG00000130522


Database:KEGG pathway       Name:Bladder cancer       ID:05219
C=42; O=2; E=0.10; R=19.75; rawP=0.0047; adjP=0.0106
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000124762 NA CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1026 ENSG00000124762
2  ENSG00000136997 NA MYC v-myc myelocytomatosis viral oncogene homolog (avian) 4609 ENSG00000136997


Database:KEGG pathway       Name:Jak-STAT signaling pathway       ID:04630
C=155; O=3; E=0.37; R=8.03; rawP=0.0064; adjP=0.0115
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000137193 NA PIM1 pim-1 oncogene 5292 ENSG00000137193
2  ENSG00000027697 NA IFNGR1 interferon gamma receptor 1 3459 ENSG00000027697
3  ENSG00000136997 NA MYC v-myc myelocytomatosis viral oncogene homolog (avian) 4609 ENSG00000136997


Database:KEGG pathway       Name:Amino sugar and nucleotide sugar metabolism       ID:00520
C=48; O=2; E=0.12; R=17.28; rawP=0.0060; adjP=0.0115
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000131459 NA GFPT2 glutamine-fructose-6-phosphate transaminase 2 9945 ENSG00000131459
2  ENSG00000117143 NA UAP1 UDP-N-acteylglucosamine pyrophosphorylase 1 6675 ENSG00000117143




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).